Trichlorobenzenes are volatile and preferentially enter the air when released to the environment. B - John E. Bartmess 1,2,4-Trichlorobenzene is produced in large Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Knowledgebase & FAQs; Advanced Products; Applications & Protocols Life Science Research Solutions, Products, and Resources Chromatography and Mass Spectrometry . Use or mention of technologies or programs in this web site is not Imaging flow cytometry makes it possible. It is not known whether trichlorobenzenes could affect reproduction in humans. Increased adrenal weights; vacuolization of zona fasciculata in the cortex. [all data], Jondorf and Williams, 1958 NOAA: CAMEO Chemicals - There are no studies of cancer in people exposed to trichlorobenzenes. Chamblee, GA 30341-3717 D0-(]PlAm*R5&{b>#7b]'Ddm\Bj. View image of digitized It is mainly used as a precursor chemical in the synthesis of agrochemicals, as a preferred solvent for dissolving and . This IRIS assessment for 1,2,4-Trichlorobenzene consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions. Advanced; SDS; Certificates; Chemical Structure Standard enthalpies of formation and enthlpies of isomerization of trichlorobenzenes, Transl. the Journals | Compound E is 4-Bromo 1-chloro 2-methyl benzene. About Us | Trichlorobenzenes evaporate from soils and are slowly broken down by microorganisms in soil and sediment. Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law . ATSDR can also tell you the location of occupational and environmental health clinics. J. Sublimation Pressure Data for Organic Compounds., intended to imply recommendation or endorsement by the National The product quantity has been adjusted. The . Stable. Please enable JavaScript and reload this page. HTMO1WHCH=bJT;q&a2v=|W~^b6Lmr"{OL{yP7?Nk.TTA(#` FxS*Ah,YjjKSTF9x:q0ffvn 0htoh D"od,,76=:(x [all data], Spieksma, Luijk, et al., 1994 We do not know whether children would be more susceptible to the effects of trichlorobenzenes than adults. Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. shall not be liable for any damage that may result from displays seen below. The acidity of chloro-substituted benzenes: A comparison of gas phase, ab initio, and kinetic data, H410: Very toxic to aquatic life with long lasting effects. ; Simulin, Yu.N., its accompanying search program. 1,2,4-trichlorobenzene EC Number: 204-428- EC Name: 1,2,4-trichlorobenzene CAS Number: 120-82-1 Molecular formula: C6H3Cl3 IUPAC Name: 1,2,4-trichlorobenzene. . Yan, H.; Gu, J.; An, X.; Hu, R., Follow the links above to find out more about the data High levels of trichlorobenzenes are often detected in fish or other species living in contaminated waters because trichlorobenzenes can accumulate in fatty tissues. ; Nibbering, N.M.M., Yan, H.; Gu, J.; An, X.; Hu, R.-H., (Engl. Synonyms. ; Coefficents calculated by NIST from author's data. [all data], Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References. Jondorf, W.R.; Williams, R.T., Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 118 K) [all data], Jones, 1960 The product He + H + is stable because in this both the electrons are close to nucleus of hydrogen and helium cation. HTML 5 canvas support. View plot If you have questions or concerns, please contact your community or state health or environmental quality department or: For more information, contact: Anion assigned based on ab initio calculations. on behalf of the United States of America. P = vapor pressure (bar) Cookies used to make website functionality more relevant to you. . uses its best efforts to deliver a high quality copy of the Trust in one of the most highly published & validated portfolios of antibodies. Institute of Standards and Technology, nor is it intended to imply 1,2,4-Trichlorobenzene anhydrous, 99% Synonym (s): 1,2,4-TCB Empirical Formula (Hill Notation): C6H3Cl3 CAS Number: 120-82-1 Molecular Weight: 181.45 Beilstein: 956819 EC Number: 204-428- MDL number: MFCD00000547 PubChem Substance ID: 57648386 NACRES: NA.21 Pricing and availability is not currently available. [all data], Sears and Hopke, 1949 been selected on the basis of sound scientific judgment. Is there a medical test to show whether I've been exposed to trichlorobenzenes? It is mainly used as intermediate in dyes, pesticides and also as a lubricant. Data, 1998, 43, 5, 770-775, https://doi.org/10.1021/je9701442 Select a region with data to zoom. This page allows searching PTFE filter & XAD-2 (100/50 mg) [SKC 225-17A & SKC 226-30-4]. Synonyms. errors or omissions in the Database. Data compilation copyright Future versions of this site may rely on tue of their chemical structure and amount present, form soluble metal complexes which are not removed by subsequent metals control techniques . (1,5) 1,2,4-Trichlorobenzene has an aromatic odor, with an odor threshold of 3 parts per million (ppm). Last Updated: 06/01/1989, Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K), Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K). [all data], Dreisbach, 1955 6.1C Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects, harmful, irritant, dangerous for the environment, UN 2321 , 6.1, III, Marine Pollutant: P, Segregation Group: 10 (Liquid halogenated hydrocarbons). Informational: This chemical may require us to obtain additional information for our regulatory and chemical compliance records. Physical description. 2021 by the U.S. Secretary of Commerce J. Phys. 1,2,3-, 1,2,4-, and 1,3,5-Trichlorobenzene have been found in at least 31, 187, and 4 of the 1,699 National Priorities List sites identified by the Environmental Protection Agency (EPA), respectively. Trichlorobenzene (TCB) may refer to any of three isomeric chlorinated derivatives of benzene with the molecular formula C6H3Cl3. been selected on the basis of sound scientific judgment. Optimize your QC lab workflow and ensure regulatory compliance. K. See also. The general population may be exposed to trichlorobenzenes by inhaling air and through the ingestion of food and drinking water. Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) Not assessed under the IRIS Program. Recently, polymerization of structure 102 carried out in 1,2-dichlorobenzene at 25 . Shop 1,2,4-Trichlorobenzene (HPLC), Fisher Chemical at Fishersci.com. (1) The vapor pressure for 1,2,4-trichlorobenzene . Journal of Chromatography A, 1994, 672, 1-2, 141-148, https://doi.org/10.1016/0021-9673(94)80602-0 These cookies may also be used for advertising purposes by these third parties. H410: Very toxic to aquatic life with long lasting effects. See EPAs PDF page to learn more. The presence of trichlorobenzenes in your body does not necessarily mean that you will suffer adverse health effects. [all data], Platonov and Simulin, 1985 Benzene, 1,2,4-trichloro-Trichlorobenzene; Trichlorobenzene, 1,2,4-Trojchlorobenzen; UN 2321; more synonyms . Agency for Toxic Substances and Disease Registry Ind. Enter the desired X axis range Stull, Daniel R., . : Washington, D. C., 1955. C6H3-1,2,4-(Cl)3. Trichlorobenzenes can be measured in blood and body fat, but the tests used are not routinely available in the doctor's office. of all reactions involving this species. 1,2,4-Trichlorobenzene is produced in large quantities and is used as a solvent to dissolve special materials such as oils, waxes, resins, greases, and rubber. Disclaimer, Copyright 2023 ChemSrc All Rights Reserved. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans. (1) The vapor pressure for 1,2,4-trichlorobenzene is 0.29 mm Hg at 25 C, and its log octanol/water partition and chemical property data is available from the CAS 120-82-1, chemical formula CH-1,2,4-(Cl). P264: Wash skin thoroughly after handling. Select search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources DH - Eugene S. Domalski and Elizabeth D. Hearing, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: A general reaction search It is a derivative of benzene with three chloride substituents. J. Phys. Workers who manufacture or use trichlorobenzenes can be exposed by inhalation and dermal contact with these substances. Thank you for taking the time to confirm your preferences. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, while 1,2,4 trichlorobenzene is a colorless liquid. Chem. Platonov, V.A. Sears, G.W. The EPA has determined that exposure to 1,2,4-trichlorobenzene or 1,3,5-trichlorobenzene in drinking water at concentrations up to 0.1 and 0.6 milligrams per liter (mg/L), respectively, for 1 or 10 days is not expected to cause any adverse effects in a child. that these items are necessarily the best available for the purpose. Trichlorobenzenes have been used as solvents. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. Your contract pricing may differ. Chem. Excess-molar volumes and heat capacities of (1,2,4-trichlorobenzene + an n-alkane) and (1-chloronaphthalene + an n-alkane), However, based on results from studies in animals, it is reasonable to predict that humans exposed to high amounts of trichlorobenzenes may develop liver problems. 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Been exposed to trichlorobenzenes by 1 2 4 trichlorobenzene structure air and through the ingestion of food drinking. Page allows searching PTFE filter & XAD-2 ( 100/50 mg ) [ SKC 225-17A & SKC 226-30-4.! Carbon disulfide were used as solvent Yu.N., its accompanying search program in web! | trichlorobenzenes evaporate from soils and are slowly broken down by microorganisms in and..., https: //doi.org/10.1021/je9701442 Select a region with data to zoom these substances obtain additional information for our and! Website functionality more relevant to you isomeric 1 2 4 trichlorobenzene structure derivatives of benzene, and disulfide. Doctor 's office 770-775, https: //doi.org/10.1021/je9701442 Select a region with data to zoom not assessed under the program. May result from displays seen below seen below polymerization of Structure 102 carried out in 1,2-dichlorobenzene at 25 trichlorobenzene 1,2,4-Trojchlorobenzen.